Guillain-barre Syndrome and Idiopathic
نویسندگان
چکیده
To the Editor: We report the case of a 3 year-old girl with Guillain-Barre syndrome and idiopathic thrombocytopenic purpura. She was admitted to the Children's Hospital of Tunis because she suddenly developed, some days after an upper respiratory tract infection, bilateral and symmetric weakness of the lower limbs. During the first week, she suffered from abdominal muscle weakness with moderate respiratory insufficiency and became unable to walk or stand without support. The clinical evaluation revealed a hypotonic paraplegia with total absence of the deep tendon reflexes. The CSF contained 60 mg% of protein with normal cell count. After ten days of evolution, she was noted to have fever and extensive purpuric spots. The full blood cell analysis and the bone marrow film confirmed a diagnosis of idiopathic thrombocytopenic purpura. This observation suggests the possibility that the same antibody may be directed against platelets and one of the main proteins of the peripheral nerves, and could be responsible for the two diseases. Platelet antibody assays could be performed in all cases of Guillain-Barre and idiopathic thrombopenic purpura. Immunological studies of peripheral nerve, using platelet antibody may be useful to verify whether this antibody is directed against the nerve. Faouzia Khaldi* Abdelmajid Larnaout** Najoua Miladi** Bechir Bennaceur* ^Children Hospital of Tunis Jabbari, Tunis **National Institute of Neurology La Rabta, Tunis
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